Dramatic changes in transcription factor binding over evolutionary time
نویسندگان
چکیده
منابع مشابه
Decoupling of evolutionary changes in transcription factor binding and gene expression in mammals.
To understand the evolutionary dynamics between transcription factor (TF) binding and gene expression in mammals, we compared transcriptional output and the binding intensities for three tissue-specific TFs in livers from four closely related mouse species. For each transcription factor, TF-dependent genes and the TF binding sites most likely to influence mRNA expression were identified by comp...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2010
ISSN: 1465-6906
DOI: 10.1186/gb-2010-11-6-122